Abstract
Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine.
Copyright © 2013. Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / chemical synthesis
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Allyl Compounds / chemistry*
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Allyl Compounds / metabolism
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HEK293 Cells
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Propylamines / chemical synthesis*
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Propylamines / chemistry
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Propylamines / metabolism
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Protein Binding
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / chemistry
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Psychotropic Drugs / metabolism
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Receptors, Serotonin / chemistry
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Receptors, Serotonin / metabolism
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Serotonin Receptor Agonists / chemical synthesis
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Serotonin Receptor Agonists / chemistry
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Spectrophotometry, Ultraviolet
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Tryptamines / chemical synthesis
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Tryptamines / chemistry*
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Tryptamines / metabolism
Substances
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Allyl Compounds
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Indoles
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Propylamines
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Psychotropic Drugs
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Receptors, Serotonin
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Serotonin Receptor Agonists
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Tryptamines
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N,N-diallyl-5-methoxytryptamine